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Inhibition of -catenin signaling in the skin rescues cutaneous adipogenesis in systemic sclerosis: a randomized, double-blind, placebo-controlled trial of C-82

The synthesis and remodeling of Acan occurs at early stages of cartilage formation and remains low during the middle and late stages [59,60,61], while Col-2 expression is consistently high throughout the early and late stages of cartilage formation [62]

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These areas (upper arms, outer-upper thighs, and belly area) have fewer blood vessels than muscle, which allows nutrients to absorb more slowly and consistently over time