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FIGURE 41.3 Histologic findings of early-stage primary sclerosing cholangitis, demonstrating prominent cholangiectasis and fibrosing cholangitis of an interlobular bile duct (hematoxylin/eosin stain 100)

The Minimal Effective Dose (MED) Plateau : This observation suggests that the dose-response curve for BPC-157 is extremely steep at the lower end but quickly plateaus