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Di(1-phthalimidyl)disulfane ( 1b ) reagent developed by Harpp 30 , which avoids the disadvantage of acidity with S 2 Cl 2 , still remains less selective and efficient owing to the nondistinctive S-N bonds

5 This led to the suggestion that polyphenol-mediated decrease in intrinsic GSH or efflux can sensitise lymphoid cancer cell lines to topoisomerase II inhibitors, which results in the synergistic and additive induction of apoptosis

[35] This high requirement for NAD + results from the constant consumption of the coenzyme in reactions such as posttranslational modifications, since the cycling of NAD + between oxidized and reduced forms in redox reactions does not change the overall levels of the coenzyme