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In BF Pol I and Pol , the BP moiety lies in the minor groove and is directed toward the 5 of the template strand, adopting the conformations similar to the ones observed in the free DNA in solution 44, 57

Enzyme-linked immunosorbent (ELISA) assay Commercially available ELISA kits were used for the assessment of mitochondrial transcription factor A (TFAM), peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mammalian target of rapamycin (mTOR), Cyclin D1, nuclear factor erythroid 2-related factor 2 (Nrf2) and Heme Oxygenase-1 (HO-1, MyBioSource, Inc., San Diego, CA, U.S.A.) according to manufacturers instructions using Spectro UV-VIS Double Beam PC Scanning Spectrophotometer (Labomed Inc., Los Angeles, CA, U.S.A.)

High concentrations of bisphenol-A also reduce the number of neurons and significantly increases the number of glial cells located in the rat DG, suggesting a pro-glial differentiation effect on proliferating NSPCs (Tiwari et al., 2015b)

It was well established that the hepatotoxicity of APAP begins with the metabolic conversion of APAP to its reactive metabolite (N/-acetyl-p-benzoquinone imine, or NAPQI) (Wallace, 2004)