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NADH and NADPH oxidases leak ROS as part of its operation

doi: 10.1038/s41467-024-50950-5 308 SinhaAKLaursenMFBrinckJERybtkeMLHjrneAPProchzkovNet al

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This alteration in the intestines increases permeability of the intestinal wall, causing disturbances in fluid metabolism, disruptions in intestinal microbial balance, translocation of bacteria from the intestines into the circulatory system, and a increase in endotoxins, thereby promoting a characteristic inflammatory state (Xu et al., 2024)