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Several preclinical studies in animal models have suggested that GLP-1 receptor agonists may reduce nicotine-seeking behaviour and attenuate the rewarding effects of nicotine

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Bupropion lacks interaction with most major receptor classes [8], but it inhibits [ 3 H]-dopamine uptake (IC 50 = 2 M) and [ 3 H]-norepinephrine uptake (IC 50 = 5 M) by rat brain synaptosomes [9]