melanotic hyperpigmentation

melanotic hyperpigmentation Oral Mucosal Melanosis Smoker's melanosis - Wikipedia

Name: melanotic hyperpigmentation Oral Mucosal Melanosis Smoker's melanosis - Wikipedia
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Smoker's melanosis Wikipedia Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics HIVAssociated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample Chandran 2016 AIDS Research and Treatment Wiley Online Library Pigmented Lesions of the Oral Mucosa Pocket Dentistry

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Description

RNA-seq transcriptomic analysis demonstrated significant dysregulation of immune-related pathways, accompanied by elevated pro-inflammatory cytokines (e.g., IL1B , TNF ) and decreased anti-inflammatory cytokines (e.g., IL4 , IL10 )

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A 1395, 136142

however, persistent or dysregulated activation can drive neurodegeneration through inflammatory signaling, metabolic imbalance and synaptic disruption