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The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials

In one melanoma study, mice exposed to higher NAC doses experienced greater metastatic activity than those given lower doses, suggesting the effect may be dose-dependent in certain experimental settings.42 Researchers have not established whether these findings apply to humans, but starting with a moderate dose offers a more conservative approach while still aligning with a large portion of the clinical literature

[DOI] [PubMed] [Google Scholar] 77.McGarrity T.J., Amos C.I., Baker M.J

Investigative work involving gene expression profiles and describing gene mutations of cellular proteins involved in tissue fibrosis and plaque calcification is most relevant