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In this context, radio- and chemo-resistant GSCs present a metabolic adaptation presenting a reduced glucose dependence, an improved lipid catabolism, ROS, mitogen-activated protein kinases (MAPKs) activity, and NAD + level, and an amplified SIRT1/PGC1 axis that promotes autophagy, resulting in an increase in the maintenance and repair machinery (Ye et al., 2013)

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