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TAD 600mg can be effective within 4 hours of taking the injection

Cell Immunol (2001) 210(1):6675

ROS is a catalyst for activation of NLRP3 inflammasome, thereby recruiting macrophages and neutrophils (163)

Taking magnesium with food will certainly reduce the risk of stomach upset, but even then, some forms like -citrate or -oxide can cause loose stools or diarrhea in some people