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In the liver, intrahepatic sympathetic nerves predominantly course along the portal triads, forming dense periportal and perisinusoidal plexuses that extend toward centrilobular regions 15,16

Diabetes 63 (10), 32793294

2d) reveals the presence of a hook effect

The development of resistance is associated with multiple factors, including genetic mutations, adaptive changes in the tumor microenvironment, and epigenetic dysregulation