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Considering the recent surveys that document much improved safety of kratom compared to the prescription or illicit opioids 83,93,94 , a further decrease of MORs G protein signaling efficacy of the key mediator of kratoms opioid-like effects, 7OH 17 , may lead to even safer compounds, and illustrates the potential importance of the present work

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While the results of the sleep duration were varied, the majority of subjects reported a decrease in the number of times awakened during the night