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(ii) xanthine oxidoreductase (XOR) metabolism

Hair was observed: In stopper areas In proximity to the product In some cases, in direct contact with a sterile drug product Affected: Multiple drug products Multiple customers Both before and after Novo Nordisk acquisition Investigations: Were not initiated in a timely manner Lacked supporting data for assigned root causes Were not expanded to include potentially impacted batches or products Failed to assess CAPA effectiveness Trending: Ineffective due to restricted search terms and limited timeframes defined in procedures Batch disposition: Contaminated units were culled Remaining units were released Customers later reported the same contamination in the received product At least (b)(4) batches associated with mammalian hair were released post-acquisition Media Fill Failures More than five media fill batches have been terminated since November 2023

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IOP Publishing, p 012149 (2021) Maddali, H., Miles, C.E., Kohn, J., OCarroll, D.M.: Optical biosensors for virus detection: prospects for SARS-CoV-2/COVID-19