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OBiO Technology, Shanghai, China) carrying a short hairpin RNA targeting GADD45 (pscAAV-U6-shGADD45-CMV-EGFP-tWPA) was constructed (AAV-shGADD45)

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Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection (Cardona-Gmez et al., 2006)