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These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations

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In large cohorts (over 3,000 rats tested) male rats sexual activity, measured by the number of ejaculations per test, displays an inverted U-shaped distribution curve (Olivier et al., 2022)