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In addition, immune complexes activate the complement system and induce NLR family pyrin domain containing 1 (NLRP1) inflammasome activation to release IL-1, thus dysregulating pro-inflammatory pathways (60, 92)

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Excessive mtROS production and subsequent activation of inflammasomes play a critical role in the pathophysiology of sepsis, driving uncontrolled inflammation and multi-organ failure

doi: 10.1016/j.urology.2013.03.065 34 Fong-NgernK.VinaiphatA.ThongboonkerdV