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Compared with traditional means of inactivation and attenuation, obtaining attenuated bacteria by knocking out virulence factors through genetic engineering techniques not only reduces the pathogenicity of the bacteria but also preserves their tumor-targeting properties

Clynick B, Corte TJ, Jo HE, Stewart I, Glaspole IN, Grainge C, et al

As illustrated in Figure 4, the gut microbiota serves as a central hub in diabetic lung injury, where gut-derived metabolites and toxins (e.g., LPS, BCAAs) remotely regulate pulmonary inflammation and immune responses through systemic circulation, ultimately leading to endothelial disruption and oxidative stress

These may include redness, swelling, and pain at the injection site