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The resultant oxidative stress induces macromolecular oxidation of proteins, lipids and DNA/RNA, leading to lipid peroxidation of biomembranes, denaturation of intracellular proteins and enzymes and DNA damage

Section 1833(g)(5)(E) of the Act states that CMS shall identify and conduct targeted medical review using factors that may include the following: (1) The therapy provider has had a high claims denial percentage for therapy services under this part or is less compliant with applicable requirements under this title

The SS-31-modified DOX-loaded liposome delivery system LS-DOX can effectively cross the blood brain barrier (BBB) to target gliomas, and mitochondrial targeting of SS-31 can enhance cellular uptake (182)