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In infants diagnosed with AD, thiols have been found to be significantly reduced compared to in comparison to healthy controls, while disulfide levels were markedly elevated, indicative of dysregulation in the thiol/disulfide balance favoring peroxidation (63)

A placebo-controlled phase 2 RCT testing pimavanserin in 117 PD patients with moderately severe ICDs has been completed but results have not yet been made public (PIMPARK study, NCT03947216)