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Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, Khainovski N (2004) Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

Research Insights Studies reveal that individuals with autism frequently exhibit lower levels of glutathione compared to neurotypical peers

2009 Jan 1;15(1):226-37

While the folate cycle is essential for generating most of the methyl groups for purine synthesis and reductive power in the mitochondria in the form of FADH2 and NADPH, the methionine cycles primary role is generating the universal methyl donor S-adenosylmethionine (SAM), regenerating methionine, and producing polyamines such as spermine and spermidine (Sanderson et al., 2019) (see, Figure 1, Methionine and salvage cycle)