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These results led us to directly examine the benefits of NQO1 transgenesis (NQO1-Tg), and its contribution to improved insulin sensitivity and metabolic dysfunction by performing an integrated analysis of physiological data, histological changes, and omics profiles from serum and metabolically active tissues such as liver, skeletal muscle, and visceral fat in mice fed either standard diet (SD) or high-fat diet (HFD)

[0319] In some embodiments, the compositions comprise an anti-acne ingredient (e.g., salicylic acid)

Subsequently, Erastin-induced pregnant rats exhibited a lower embryo survival rate, fetal growth restriction (FGR), and reductions in placental diameter and weight compared to the Sham group (Fig

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