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Lin discovered that oxidative stress might decrease the expression of the histone-lysine N-methyltransferase EZH2 and the level of lysine 27 of the histone H3 protein in GCs while increasing the expression of Interleukin-1 receptor type 2 to suppress ovulation signals (77)

BV and melittin also effectively inhibit the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 cells without cytotoxic effects

Most research highlights only mild and temporary side effects, such as minor digestive discomfort or occasional gas, linked to oral consumption

The core difference is how many gut hormone pathways each drug uses