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[DOI] [PMC free article] [PubMed] [Google Scholar] 326.Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S, Sun R, Wang Y, Hu B, Chen W, Zhang Y, Wang J, Huang B, Lin Y, Yang J, Cai W, Wang X, Cheng J, Chen Z, Sun K,Pan W, Zhan Z, Chen L and Ye F, J

Talwar*, Arie Croitoru, Andrew Crooks, A

In addition, the human glioma TME has many immunosuppressive cells, such as M2 macrophages and Tregs, whose presence usually inhibits the activity and function of T cells and is associated with reduced overall survival of patients (179181)

Their biological effects stem from the conjugated double bonds in their long polyene chain, which enable them to inhibit reactive oxygen species and reduce oxidative damage [173]