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However, under conditions of iron overload, excess Fe 2+ in the LIP undergoes Fenton chemistry with H 2 O 2 , producing excessive ROS, promoting lipid peroxidation, and ultimately triggering ferroptosis (Zhao et al., 2025a)

Shock 34:9097 Yuan J, Wang D, Liu Y, Chen X, Zhang H, Shen F, Liu X, Fu J (2018) Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway