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PMID 29088702

When bound to the target protein, these create an altered protein-ligand interface that is recognised by a ligase

Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ, Mikus CR, Laye MJ, Laughlin MH, Booth FW, Ibdah JA

Among them, compound 8u becomes the most effective xanthine oxidase inhibitor, with an IC50 value of 0.0288 mM, which is equivalent to febuxostat (IC50 0.0236 mM) (Zhang et al., 2019)