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Congential Glutamine Synthetase Deficiency: What lessons can we learn

Injection into sensitive or low-fat tissue: Areas such as the abdomen, inner thigh, or other sites with minimal subcutaneous fat have less tissue cushioning and a higher density of sensory nerve endings, making pH-related discomfort more noticeable

doi: 10.1007/s00726-007-0471-2

Betaine supplementation has been used for over 40 years to support individuals with genetic defects of folate dependent remethylation because betaine is known to increase methionine concentration and aid homocysteine reduction