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Regulatory T cells, myeloid-derived suppressor cells and tumor-associated macrophages skewed toward an M2-like phenotype accumulate, while immunosuppressive mediators are upregulated, keeping local immune reactivity at a low level [14, 16]

However, recent research has increasingly highlighted the potential of Chinese botanical drugs in improving histological features and modulating signaling pathways associated with OS in ALD, underscoring the therapeutic potential of traditional Chinese herb medicine