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Description

As a result of a decreased glomerular filtration rate, metabolic disorders and renin-angiotensin system activation, hypertension is often accompanied by DKD

Its mechanism is completely different from any of the GH-axis peptides described above

Prekallikrein can be directly activated by FXII to kallikrein, which in turn activates more FXII to FXIIa, creating a positive feedback loopthe intrinsic tenase complex