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For example, UFD-2 is required for SKN-1 activity but not PMK-1 activation (Figures 4B, and 6, see Additional file 2: Figure S6)

Under iron-deficient conditions, IRPs suppress the translation of these proteins, increasing labile iron pools and sensitizing cells to ferroptosis through enhanced lipid peroxidation [64]

4d), among which six ferroptosis-inhibiting genes (Slc7a11, Slc40a1, Gclm, Fth1, Gclc, and Gss) were upregulated, one ferroptosis-promoting gene (Slc39a14) was downregulated, and one ferroptosis-promoting gene (Hmox1) was upregulated

Using GHK-Cu: apply to clean skin, typically as a serum, once or twice daily