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Nadarajah, V

SIRT 1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence

The crystals were then flash-frozen in liquid nitrogen, and data were collected at the Diamond Light Source beamlines I04 and I04-1 and processed automatically using the Xia2 Dials pipeline 53,54

High-dose VitC thus leads to ROS formation and thereby targets redox imbalance, which results in DNA, protein and lipid damage of cancer cells [15, 30, 38]