paracetamol glutathione PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses N-Acetylcysteine & Paracetamol Poisoning Rescue

Wiki-Pi Home About People Search Wiki-Pi GSTM2 Name glutathione S-transferase mu 2 Structure Interactors 3 interactors: GSTM1 GSTM3 PTEN GO Annotations Cellular Component Cytoplasm Cytosol Sarcoplasmic Reticulum Extracellular Exosome Molecular Function Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding Transferase Activity Calcium Channel Inhibitor Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding Transmembrane Transporter Binding Biological Process Lipid Metabolic Process Glutathione Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Relaxation Of Cardiac Muscle Cellular Detoxification Of Nitrogen Compound Cellular Response To Caffeine Cellular Oxidant Detoxification Pathways Glutathione conjugation Drugs Glutathione S-(2,4-dinitrophenyl)glutathione Glutathione disulfide Glutathione disulfide Deoxycholic acid S-Methyl glutathione GWAS Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) LDL cholesterol levels ( 32203549 ) Metabolite levels ( 31628463 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Entrez ID 2946 HPRD ID 00710 Ensembl ID ENSG00000213366 Uniprot IDs P28161 Q0D2I8 PDB IDs 1HNA 1HNB 1HNC 1XW5 1YKC 2AB6 2C4J 2GTU 3GTU 3GUR 5HWL GO Terms Enriched among Interactors

Glutathione binds to mercury so that it can be removed from tissues

Based on these limitations, future research should integrate detailed exposure metrics, genetic profiling, and chronotype assessments to better clarify mechanisms and identify high-risk subgroups

Kidney detoxification, acidic pH and adenosine disposal The Acidic pH and Impaired Clearance Epigenetic Biotype of Undermethylation is not based on urine pH alone