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Elevated homocysteine levels are associated with increased risk of heart attack, stroke or dementia

Medical conditions: Certain health conditions, such as diabetes, thyroid disorders, nerve compression (radiculopathy), spinal stenosis, and liver disease (e.g., cirrhosis), can increase the risk

Its primary job is to block an enzyme called nicotinamide N-methyltransferase, or NNMT

Although FOXO4s specific effects on mitochondria are as direct as the other peptides above, it is known to regulate the expression of genes involved in oxidative stress response and energy metabolism, which can impact mitochondrial function indirectly (Liu, 2019)