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Changes in circulating histamine were examined by mass spectrometry

To maintain redox homeostasis, neurons rely on antioxidant systems such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) to neutralize free radicals

The evidence that hypotaurine, through its binding to soluble A, reduces the production and aggregation of oligomers, as well as its ability to lessen the toxicity of -amyloid (A) in primary cultured neurons and amyloid plaques in a mouse model, provides support for this assertion (129)