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It was found that both sensitive and resistant CRC tissues and cells showed high levels of Notch1 expression

Together with adaptive treatment paradigms and combination strategies, heterogeneity-focused clinical trials represent a critical step toward operationalizing evolutionary oncology in routine cancer care

Acknowledgements This work was supported by grants from the Singapore Ministry of Education Academic Research Fund (T1-2011 Sep-05 and T1-2014 Apr -05) awarded to YC Long