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Small molecule drugs have always been the preferred molecules for the development of intracellular target drugs due to their good stability, high oral bioavailability, and enhanced cell penetrability

Targeting Glycolysis Delays the Onset of T1D in an Adoptive Transfer Model Based on the ability of PFK15 treatment to reduce BDC2.5 T cell responses, we examined the impact of glycolysis inhibition on the onset of diabetes using an adoptive transfer model ( Figure 3A )

Fresh isolation of white blood cells and ROS detection Blood samples were collected from rats before and 1 h after glucose challenge (gavage of 2 g/kg body weight)