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Description

Cell cycle checkpoint genes, including ATM, CHEK1, and TP53, monitor genomic integrity and prevent the transmission of damaged DNA to daughter cells [394]

Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence

In this review, we discuss the possible importance of ferritin in non-APL (acute promyelocytic leukemia) variants of AML: In the first part, we briefly describe the most important structural and functional characteristics of ferritin (Section 2), including its effects on AML-supporting bone marrow stromal cells and especially endothelial and immunocompetent cells (Section 3)