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Y.ChenS.ZhangY.CaiL

Caffeic acid, as a substrate of catechol-O-methyltransferase, is methylated to SAH, which further inhibits DNMT1 (Zhu and Zhu, 2006)

Another macrolide, FK506, was already known for its immunosuppressive properties, being successful as a transplant drug (tacrolimus), but its mechanism of action differed from that of rapamycin