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NNMT inhibition increases adipose [S-adenosylmethionine (SAM)] and [Nicotinamide adenine dinucleotide (NAD+)] levels As youll discover later on in this article, theres a good reason why increased production of SAM and NAD+ within fat cells is beneficial

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This avoids over-supplementation in patients who do not need a particular nutrient, and it also avoids the false reassurance of shotgun supplementation covering up an actual problem

In the non-responders, only a small but significant increase in vitamin B12 levels was observed