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The recently completed Phase 3 TRIUMPH-4 trial confirmed this, showing 28.7% average weight loss (71.2 lbs) at 68 weeks with the weekly 12 mg dose

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575 Similarly, the loss of mitochondrial complex I leads to a decrease in the ratio of NAD + /NADH and can inhibit the activity of Sirt3, thereby enhancing the protein acetylation and mPTP sensitivity

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