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[192] engineered the FN III 9-10 and FN III 12-14 fragments through genetic manipulation, resulting in the development of a recombinant FN fragment, FN III 9-10/1214 , which was subsequently covalently conjugated to the fibrin scaffold

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This research-grade amino acid sequence selectively targets senescent cells to induce apoptosis, addressing age-related cellular dysfunction observed in aged mice studies

The typical target is the ventral posteromedial nucleus of the thalamus (Fig