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Where These Numbers Come From NAD+ replenishment targets several interconnected aging pathways, all driven by the age-related decline in NAD+ levels: Sirtuin activation: NAD+ is required for SIRT1-7 function deacetylases that regulate DNA repair, mitochondrial biogenesis, inflammation, and stress resistance

313 The content of PGF2 and its receptor FP are both upregulated in the liver under diabetic stress, and the increased FP could bind to Gq to elicit Ca 2+ and activate CaMKII-FOXO1 signaling to enhanced gluconeogenesis in hepatocytes

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Statistical analysis and data graphing were performed using IBM SPSS 26.0, GraphPad Prism 8.0.1, and R 4.3.2