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Furthermore, increased strand breaks generation caused activation of poly(ADP-ribose) polymerase (PARP), a zinc finger DNA-binding protein, known to deplete intracellular NAD + reserves as well as energy stores, thus ultimately resulting in cell death (429)

Additionally, in the context of relatively healthy cohorts like aged or overweight individuals, or even in obese cohorts, NAD + modulation by NR did not correspond to significant changes in mitochondrial homeostasis 314,316,321,335,336

A study on ESCC patients receiving neoadjuvant chemotherapy found that the decline in PALB levels after treatment, rather than the absolute value, was more effective in predicting postoperative pulmonary complications (81)

a, b, c FAO and IIASA: Harmonized World Soil Database version 2.0, FAO, Rome and Laxenburg, 2023