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This mechanism is considered a physiological basis of the behavioral sickness response that humans and animals display during infections (Poon et al., 2015)

It has been documented in a meta-analysis study and a systematic review that elevated levels of 8-OHdG in biological samples, such as urine, serum, or tissue, are indicative of increased oxidative stress (182, 183)

Statistical analysis Data throughout the experiment are presented as mean standard deviation (SD) or mean standard error (SEM), analyzed using GraphPad Prism

It acts as a cofactor for two critical enzymes: methionine synthase, which is involved in DNA methylation and homocysteine metabolism, and methylmalonyl-CoA mutase, which participates in fatty acid metabolism