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From a neuroscience perspective, these interventions help the brain transition more safely back toward equilibrium rather than forcing an abrupt and overwhelming recalibration

References 1 AdakA.KhanM

doi:10.1021/bi973101r

It is important to note in this model that CDDO-Im was administered after injury, which, along with the chronic activation induced in the Keap1 FA/FA model, supports the notion that NRF2 can promote diabetes progression following onset of the pathology