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Nature 511:319325

The mechanisms that make peptides effective for pollen allergies (mast cell stabilization, NF-kB suppression, immune regulation) apply to pet allergies as well

Moreover, SLC7A11 and cyclin-dependent kinase inhibitor 1A (CDKN1A) gene expression is stimulated by the p53DPP4 interaction, thereby inhibiting ferroptosis (82)

Impaired acidification, fusion defects and reduced endosomeautophagosomelysosome pathway flux compromise the clearance of pathogenic aggregates, and raising cellular cAMP or free zinc has been proposed as a strategy to restore lysosomal pH and proteolytic capacity in affected neurons 166