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Inflammation also plays a critical role in cyclosporin-induced hepatotoxicity (El-Sherbeeny & Nader 2016

Risk factors include genetic predisposition, prenatal and birth complications, infections and immune dysfunction, and cannabis use as well as psychosocial factors such as childhood trauma or migration

doi: 10.1182/blood-2018-11-844530 204 HallakMInalABaktirMAAtaseverA

Even though treatment with rutin and aescin led to a substantial decline in TNF- and IL-6 concentrations, PTU therapy still slightly alleviated the inflammatory response, as reported by Akalin et al