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*Correspondence: Jacinta Serpa, [email protected] This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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doi: 10.1016/j.cell.2013.12.010 21 ChenYZhangFDuZXieJXiaLHouXet al