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Serotonin also is a precursor of MELATONIN , directly involved in the hair cycle with antiapoptotic and antioxidant effects BIOTIN is an important coenzyme for fat and carbohydrate metabolism: its deficiency causes alopecia, thinning, and loss of natural hair color

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A biallelic mutation (E366G) in SNIP1 , located near the FHA domain, has been associated with a complex neurodevelopmental disorder in 35 individuals from the Amish community 47,48 , although the underlying mechanistic defect caused by the mutation is unknown

CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain