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This may be due to liver or kidney disease, or certain cancers and blood disorders: The aetiological profile of high serum cobalamin predominantly encompasses severe disease entities for which early diagnosis is critical for prognosis

Spectrometric, biochemical, immunoblot, and immunohistochemical analyses were performed to assess the hepatic redox-active Fe 2+ intensity, metabolic function, anti-oxidative enzyme expression, and the pro-inflammatory cytokine levels

Summary: For most people requiring oral supplementation, cyanocobalamin is the most commonly used and effective form of B12, whilst hydroxocobalamin injections are the preferred treatment for confirmed deficiency in UK clinical practice