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Research has pointed toward taking too much B12 also leads to issues such as vitiligo (changes in skin color), atopic dermatitis (eczema), rosacea (both mild and severe), and even allergic reactions (topical and anaphylaxis)

Seek urgent medical attention for severe allergic reactions, blood in stools or vomit, or persistent severe abdominal pain after taking B12 supplements

The observed decrease in serum ferritin concentration might have been secondary to depletion of the bodys iron reserves after bariatric surgery as the prevalence of anemia in the Optimum 2.0 group increased from 13% at T24 to 18% at T36, suggesting that the bodys iron stores were not sufficient to prevent patients from developing iron-deficiency anemia

Dietary factors also influence B12 requirements